Xtandi
Astellas · Enzalutamide
Research reported by University of California Los Angeles.
$5.13B
Medicare, 2025, 48,505 patients
$1.24B in 2026 Q1
You paid twice
$16.14B
Medicare paid, 2025
for these products, before rebates
$55.00B
Medicare paid, 2020–2025
plus $3.80B in the first quarter of 2026
$69.30B
Federal contracts and grants to these companies
fiscal 2020 to date, includes vaccine purchases
79
Products from 46 companies
48 invented in government labs; 33 with grant-funded patents
Astellas · Enzalutamide
Research reported by University of California Los Angeles.
$5.13B
Medicare, 2025, 48,505 patients
$1.24B in 2026 Q1
Pfizer · Tafamidis
Research reported by The Scripps Research Institute.
$3.92B
Medicare, 2025, 19,958 patients
$1.16B in 2026 Q1
Johnson & Johnson · Apalutamide
Research reported by University of California Los Angeles.
$2.08B
Medicare, 2025, 19,179 patients
$537M in 2026 Q1
Pfizer · Tafamidis Meglumine
Research reported by The Scripps Research Institute.
$766M
Medicare, 2025, 4,141 patients
$20M in 2026 Q1
Pfizer · COVID-19 vaccine, mRNA
Licensed from NIH labs to BioNTech/Pfizer.
$646M
Medicare, 2025, 3,596,208 patients
$42M in 2026 Q1
Gilead · Emtricitabine; Tenofovir Alafenamide Fumarate
Licensed from CDC labs to Gilead Sciences.
$515M
Medicare, 2025, 30,112 patients
$114M in 2026 Q1
Invented at NIH
NIH lists Comirnaty and Spikevax among the products built on licenses from its labs, for the stabilized spike protein design its Vaccine Research Center co-invented. On top of that, Pfizer and Moderna received $54.73B in federal contracts since fiscal 2020, much of it to buy doses. See the contracts.
University of California Los Angeles
Syfovre · Apellis Pharmaceuticals
University of Pennsylvania
NIH labs
Orserdu · Stemline Therapeutics
Duke University
NIH labs
NIH labs
Zeposia · Bristol Myers Squibb
The Scripps Research Institute
Myalept · Aegerion Pharmaceuticals
NIH labs
Empaveli · Apellis Pharmaceuticals
University of Pennsylvania
NIH labs
NIH labs
NIH labs
Palsonify · Crinetics Pharmaceuticals
Crinetics Pharmaceuticals, Inc.
NIH labs
NIH labs
NIH labs
20 of these were invented in NIH, CDC or FDA labs and licensed to the company that sells them. The rest are built on university and company research that NIH grants paid for.
AcuTect, Amtagvi, Certiva, Cervarix, Dengvaxia, Ebanga, Fludara, Forzinity, Gardasil, Hemgenix, Hivid, Komzifti, Kygevvi, Lumoxiti, LYMErix, NeoTect, Neuraceq, NeuTrexin, Pedmark, Pylarify Truvu, Roctavian, RotaShield, Sporanox Oral Solution, Taxol, Tpoxx, Videx, Vitravene, Vyondys 53, Xenoview, Zenapax, Zevalin, Zinbryta
How this is built. A product is listed for one of two public records. Either NIH's Technology Transfer office lists it as an FDA-approved product built on a license from an NIH, CDC or FDA lab, or a patent the FDA lists for the drug was reported to NIH as an invention made with NIH grant money, as the Bayh-Dole Act requires. We then add what Medicare Part D, Part B and Medicaid paid for each product, and for each company, the federal grants and contracts it received, its PAC's donations and its lobbying.
What the numbers mean. Medicare and Medicaid figures are gross spending before the rebates drug makers pay back, which are confidential. Hospital-administered therapies such as CAR-T cell treatments are mostly paid under Medicare Part A and do not appear in these files. "NIH grants" is everything NIH paid on the grants a patent was reported under, from 1985 on; a grant usually paid for more than one invention, so it is not the cost of the drug. Federal contracts include purchases, such as vaccine doses, as well as research. Companies also paid for the clinical trials that took these products to approval. None of these figures shows that public money set a price or bought a decision.
Sources: NIH Technology Transfer: FDA-approved products licensed from NIH, CDC and FDA labs; NIH RePORTER patents reported under NIH grants (from iEdison); NIH RePORTER project funding; FDA Orange Book patent, exclusivity and product files; CMS Medicare Part D and Part B Spending by Drug (annual and quarterly); CMS Medicaid Spending by Drug; USAspending.gov federal grants and contracts. Updated 2026-11-06.