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You paid twice

You paid for the research. Then Medicare paid $16.14B for the drugs in 2025.

These 79 drugs and vaccines were invented in government labs or are protected by patents their inventors reported as funded by NIH grants. In 2025, Medicare paid $16.14B for them, up from $12.81B in 2024. In the first quarter of 2026 alone it paid $3.80B.
Reported

$16.14B

Medicare paid, 2025

for these products, before rebates

Calculated

$55.00B

Medicare paid, 2020–2025

plus $3.80B in the first quarter of 2026

Reported

$69.30B

Federal contracts and grants to these companies

fiscal 2020 to date, includes vaccine purchases

79

Products from 46 companies

48 invented in government labs; 33 with grant-funded patents

Patent reported as grant-funded

Xtandi

Astellas · Enzalutamide

Research reported by University of California Los Angeles.

$5.13B

Medicare, 2025, 48,505 patients

$1.24B in 2026 Q1

Patent reported as grant-fundedOrphan drug

Vyndamax

Pfizer · Tafamidis

Research reported by The Scripps Research Institute.

$3.92B

Medicare, 2025, 19,958 patients

$1.16B in 2026 Q1

Patent reported as grant-funded

Erleada

Johnson & Johnson · Apalutamide

Research reported by University of California Los Angeles.

$2.08B

Medicare, 2025, 19,179 patients

$537M in 2026 Q1

Patent reported as grant-fundedOrphan drug

Vyndaqel

Pfizer · Tafamidis Meglumine

Research reported by The Scripps Research Institute.

$766M

Medicare, 2025, 4,141 patients

$20M in 2026 Q1

Invented in a government lab

Comirnaty

Pfizer · COVID-19 vaccine, mRNA

Licensed from NIH labs to BioNTech/Pfizer.

$646M

Medicare, 2025, 3,596,208 patients

$42M in 2026 Q1

Invented in a government labOrphan drug

Descovy

Gilead · Emtricitabine; Tenofovir Alafenamide Fumarate

Licensed from CDC labs to Gilead Sciences.

$515M

Medicare, 2025, 30,112 patients

$114M in 2026 Q1

Invented at NIH

The COVID vaccines rest on an NIH patent

NIH lists Comirnaty and Spikevax among the products built on licenses from its labs, for the stabilized spike protein design its Vaccine Research Center co-invented. On top of that, Pfizer and Moderna received $54.73B in federal contracts since fiscal 2020, much of it to buy doses. See the contracts.

Every product with Medicare or Medicaid spending (47)

Sorted by what Medicare paid in 2025. A dash means the product does not appear in that spending file.

20 of these were invented in NIH, CDC or FDA labs and licensed to the company that sells them. The rest are built on university and company research that NIH grants paid for.

By company

What Medicare paid in 2025 for each company's products on this list.

Older and hospital-only products (32)

On the list but with no spending in Medicare's Part D or Part B files or Medicaid's: off the market, generic now, or paid for inside hospital stays.

How recent is this?

Medicare drug spending
full-year 2025 and the first quarter of 2026, from CMS's quarterly release; annual files run through 2024
Medicaid drug spending
through 2024; CMS has not published a 2025 file yet
Government-lab products
NIH Technology Transfer's list, newest approval 2025-02-14
Grant-funded patents
NIH's patent file and the FDA Orange Book, both downloaded 2026-11-05
Federal grants and contracts
USAspending, fiscal 2020 to date

How this is built. A product is listed for one of two public records. Either NIH's Technology Transfer office lists it as an FDA-approved product built on a license from an NIH, CDC or FDA lab, or a patent the FDA lists for the drug was reported to NIH as an invention made with NIH grant money, as the Bayh-Dole Act requires. We then add what Medicare Part D, Part B and Medicaid paid for each product, and for each company, the federal grants and contracts it received, its PAC's donations and its lobbying.

What the numbers mean. Medicare and Medicaid figures are gross spending before the rebates drug makers pay back, which are confidential. Hospital-administered therapies such as CAR-T cell treatments are mostly paid under Medicare Part A and do not appear in these files. "NIH grants" is everything NIH paid on the grants a patent was reported under, from 1985 on; a grant usually paid for more than one invention, so it is not the cost of the drug. Federal contracts include purchases, such as vaccine doses, as well as research. Companies also paid for the clinical trials that took these products to approval. None of these figures shows that public money set a price or bought a decision.

Sources: NIH Technology Transfer: FDA-approved products licensed from NIH, CDC and FDA labs; NIH RePORTER patents reported under NIH grants (from iEdison); NIH RePORTER project funding; FDA Orange Book patent, exclusivity and product files; CMS Medicare Part D and Part B Spending by Drug (annual and quarterly); CMS Medicaid Spending by Drug; USAspending.gov federal grants and contracts. Updated 2026-11-06.